Ethics in Data and Web Mining

Ethics in Data and Web Mining Liliam Faraon What is the importance of ethics in Data Mining? We live in a time when the pursuit of knowledge is indispensable. From the transformations we have witnessed in the past years, we can acknowledge that information assumes a growing importance and a requirement for any sector of human activity. Some authors say that 90% of all data in the world has been generated over the last two years, and more and more devices will be connected to the internet generating data that can be used by companies to predict patterns of consumption and increase specific sales. The article: 17 Internet of Things Facts Everyone Should Read published by Forbes in October, 2015, brings us an idea of some numbers and the potential market that is available to be exploit: Nowadays there are more objects connected to the internet than people; By the year of 2020 around 250.000 vehicles will be connected to the internet, (saving time spend in traffic, fuel, improving the performance and protecting the environment and generating data); The global wearable device market has grown 223% only in 2015 specially by the launching of Fitbit ® and Apple Watches; Internet of Things will add $10 to $15 trillion to global GDP by 2036; But looking at all the facts some questions are raised, such as: how the data we produce is managed and stored? How is it perceived? How businesses are taking advantage from all the that information? And finally, how do we protect our own data and make sure is not being used without consent? Thats where web mining poses a threat to ethical values, such as individuality and privacy. Improvements in IT and storage capacity has enabled companies to develop tools for data collection through many channels. There are a variety of ways individuals generate data, such as: ATM visits, bar-code readers, biometric devices, credit and debit card transactions, loyalty clubs, medical records, online shopping, rentals, scanners, subscriptions, website browsing and use of many Smart devices available. As a result, there is an exponential growth of the amount of data stored and available to be explored. This generation of data brought the need of new techniques and technologies that can analyse and convert all this information into useful knowledge and Data Mining becomes a very powerful resource. When all these data are merged and mined, they can infer a persons associations, credit information, health, income, political interests and tastes. Liu defines data mining as The process of discovering useful patterns or knowledge from data sources à ¢Ã¢â€š ¬Ã‚ ¦ The patterns must be valid, potentially useful and understandable. (Liu, 2011, p. 6). Data mining based on algorithms are very automated and analytical tools and its use is rapidly increasing. By combining databases, information visualisation, machine learning, mathematical modelling, pattern recognition, statistics and more recently artificial intelligence, very large and complex datasets can be analysed and relationships, patterns, outliers and trends can be revealed. Figure 1: Data Mining         Ã‚   Raw data itself is not useful at all, but the information that can be extracted from the data is where the real value seats. We have endless amounts of data being produced and stored, it makes sense companies and governments have the desire to analyse all this data to uncover patterns potentially useful hidden in there. Data Mining process is basically categorised into two classes: Descriptive: describes the general properties of information stored in a database Predictive: draws inferences from the data in order to make predictions. Witten emphasises: Data Mining is about solving problems by analysing data already present in databases (Witten, 2013, p. 4). Decision makers desire the right answers for broad questions and obviously, the more data gathered the more questions raised. Which customers are likely to respond in a positive way to a marketing campaign? What products will have more success when launched? What is the best price range for a new product? How do the competitors tend to react? The response for those questions cannot be reached based on feelings or intuition, they can be answered by analysing customers behaviour and profile using data mining tools. By collecting and summarizing and making use of data mining companies and organisations can identify insights and obtain competitive advantage, recognize potential competitors, improve customer service relationship, target customer expectations and needs. It also has important uses in social business and science, most recently Government Agencies are using Data and Web mining applications to uncover criminal activities such as terrorist threats. There are many Data Mining tools are available in the market nowadays, each one with its particularities, the most common are KNIME, NLTK, Orange, RapidMiner (formerly known as YALE), R-Programming and WEKA . Ethics must be a condition of the world, like logic. Ludwig Wittgenstein, 1889-1951. Giant social media such as LinkedIn, Facebook and Twitter hold billions of users data, keeping these data protect and as a secret is a big concern. When an individual creates an account on any of those social media channels a policy agreement is accepted, and it is basically data related. Data Mining analysts use people personal information collected by organisations all over the world through many different technologies and use them especially for prediction analysis, but practitioners must be very careful when analysing patterns, certain kinds of discrimination are not only unethical but also illegal, gender, religion, race and certain sensitive information is totally unacceptable, in the other hand, anonymizing data is very difficult, for example, over 85% of Americans can be identified from publicity available records using just three pieces of information: zip code, birth date and sex (Witten, 2013, p.33). When a person shops for a product online, the company has access to customers address, credit card, name, phone number and other information in their database. But how does the company encrypts the information and protects it from misuse or security breach is and ethical and legal issue. Some matters are also raised: Is it ethical and legal to use the users information for publicity purposes? How can users protect their right of privacy? Where does the right of a company meets the ethics when sharing its data with another company to comprehend and understand customers and increase profit by selling this information to third party companies is a very important matter and it must be carefully discussed. There is a thin line between of a persons privacy and companys right to use it. When a person provides personal information, he or she needs to know how and what it will be used and a few steps must be taken to guarantee confidentiality and integrity. The use of data particularly data about people for data mining has serious ethical implications and practitioners of data mining techniques must act responsibly by making themselves aware of the ethical issues that surround their particular application. (Witten, 2013, p. 33). There is a growing concern regarding to the use of private and sensitive information and the ethical issues of Data Mining must be analysed and understood both from the business and the personal point of view. From a personal point of view, by Data Mining execution respecting consent, privacy and regulations customers might appreciate the fact they are being target with more personalized offers based on circumstances and needs and in return they may be willing to provide more specific data about themselves. From a business point of view by respecting the privacy issues companies will save resources as they will be able to target very specific customers for certain products. It is obvious that as any other powerful technology there are negative consequences of Data Mining, some results can ineffective, misdirected or unregulated, but if used correctly it can be very resourceful. Some points are very important and organizations making use of data mining techniques should give a thought about them when the use of personal data is planned: Connectivity and data sharing All the users and people that give consent are connected through the internet and share data Security is essential Once all the information traffics through databases, companies worry about the security and privacy, that way all the data will be encrypted, the web services will be hosted in a server with a certificate installed and authentication user The importance of Privacy Policy Privacy Policy is a legal statement and regulates the privacy policy related to users personal data which is under companies responsibility Infrastructure The process will not function without an application to analyse, interpret, read and draw patterns from the data Account management: Gathering and leveraging Account Management has all the information gathered and leveraged, and elaborate can advertising campaigns. It plays an important role in the profitability of the company Information could be released without the consent of the person, it becomes an ethical dilemma, because sometimes the users are unaware of the information gathered and that is being used by companies. It is very important to highlight that the person has the right to know how it will be used and should be able to have the opportunity to consent or not the collection and use. And also when a person becomes part of a group profile and used as a decision making basis, the individuality is threatened, people cannot be judged only as group members, but also as an individual, able to make its own decisions. It is likely that in the next few years an inspection of ethical issues and legal implications will be further required, legislation of digital privacy will be developed and laws will enter force, confidentiality and privacy preservation should be the main points of concern. Unauthorised extraction of data will be considered a crime and companies must be ready for that. Data Mining algorithms are very important and powerful tools for analysis and predictions, they are expected to become more and more significant in the future, decision based on data will change the way companies base their processes, of course there are no 100% guarantee that they will succeed, but, are more likely to be successful than decisions based on feelings or gut. Once patterns are revealed profiles can be drown and stereotypes can be used for crime prevention, commercial proposes, marketing campaigns, policies development and many others. Meanwhile Data Mining ethical issues need to be raised and awareness increased, as the world continues to develop, more and more data is likely to be collected and the Data Mining processes will become more sophisticated. People will need to get a clearer idea of privacy and companies will have to become more transparent on its processes of collect, gather and use of data. Cook, Jack (2005). Ethics of data mining. Available at: http://scholarworks.rit.edu/cgi/viewcontent.cgi?article=1443context=article Ethics in Computing. Available at: https://ethics.csc.ncsu.edu/privacy/mining/study.php [Accessed: 02 March 2017]. Fule, Peter. Detecting Privacy and Ethical Sensitivity in Data Mining Results. Available at: http://crpit.com/confpapers/CRPITV26Fule.pdf Liu, Bing. (2011). Web Data Mining: Exploring Hyperlinks, Contents, and Usage Data, Springer MARR, Bernard.17 Internet Of Things Facts Everyone Should Read (2015). Available at: http://www.forbes.com/sites/bernardmarr/2015/10/27/17-mind-blowing-internet-of-things-facts-everyone-should-read/#5e463ad01a7a [Accessed: 01 March 2017]. Wahlstrom, Kirsten (2006). On the Ethical and Legal Implications of Data Mining. Available at: https://csem.flinders.edu.au/research/techreps/SIE06001.pdf Witten, Ian H (2013). Data Mining: Practical Machine Learning Tools and Techniques, Morgan Kaufmann. Zhen, Ethical issues in Web Data Mining. Available at:http://blog.nus.edu.sg/group208/2012/11/25/ethical-issues-in-web-data-mining/ [Accessed: 01 March 2017].

Ceo Safety Policy Statement

Safety Policy Statement a. Safety is paramount in all flight operations. Company X manages safety risks related to its operations to as low a level as reasonably practicable. Company X will manage safety through its dedicated commitment to implement and maintain Company X’s Safety Management System. This commitment includes the responsibility of both Company X’s management and employees to continuously improve the level of safety and never to become complacent when it comes to the safety of Company X’s operations. It is the joint responsibility of everyone connected within the flight operation to be proactive and ensure all safety hazards are identified, analyzed and, where possible, eliminated or avoided. When this is not possible, mitigation is developed, implemented and tracked to verify that the level of the associated risks are acceptable. It will also be the commitment of both management and of all employees to comply with all applicable regulatory requirements when conducting Company X’s Operation. . The purpose of the safety policy is to manage safety proactively and effectively. This is attained by utilizing the Company X SMS to: i. Identify and manage safety risks specific to the company’s flight operations. ii. Encourage employees to report safety issues without the fear of reprisal. iii. Collect and analyze information and feedback through the continuous improvement system so as to continually improve safety management activities. iv. When safety issues are discovered it is assumed that both management and the employees have shared responsibility and accountability in finding ways to fix the safety issues and in ensuring that the prescribed procedures to fix the problems are carried out and also to help notify the Director of Safety as to whether these procedures are working or not. v. Both management and the employees are expected to follow all safety procedures and policies of Company X including the reporting of all safety issues and hazards to the Director of Safety. i. The SMS program will also provide management guidance for implementing new procedures and processes to ensure that a high level of safety is maintained when these new procedures and policies are carried out. vii. The Director of Safety reviewing Company X’s safety objectives each month to ensure they are current and still applicable to Company X’s Operations. The Director of Safety will ensure that any safety objectives not meetin g current safety standards and goals will be revised as necessary. c. Company X’s safety policy also requires the full support of safety from top level management. Flight crew members, aircraft maintenance personal and others involved in the operation of Company X will always have the full support of the CEO as long as they operate professionally in accordance with company manuals and procedures. All company personnel have a duty to openly and honestly report events and hazards using the continuous improvement system. The CEO will ensure that all such reports will be thoroughly investigated in a non-punitive manner. The CEO of the company is ultimately responsible for: i. Sustaining conditions that promote the safe operation of company aircraft, ii. Ensuring that all safety related company positions, responsibilities and authorities are defined, documented and communicated throughout the company. iii. Define and publish which levels of management can make safety risk acceptance decisions in regards to company operations. iv. Providing the resources (in time and money) to assure the safe operation of company aircraft, and v. Actively supports the Safety Management System.

The 30-Second Trick for Essay Titles Samples

The 30-Second Trick for Essay Titles Samples What You Don't Know About Essay Titles Samples A requirement for college program, essays are here in order to stay. With the aid of a professional writer, your essay will be prepared within a day. If so, it needs a title. A well-written essay is fantastic. Try out professional online writing service full of talented writers who will think of the most effective, intriguing essay title and the remainder of the paper! The website is not hard to navigate and it takes not more than a moment to create the essays of your pick. Like every assignment, a descriptive essay has a certain intent. An essay generator is an alternative for those students that have problems to locate something to chat about on their essays, they don't have the creativity neither the patient to choose a topic type instead of even a subject location. ARandom topic generatoris made to help you locate the most fascinating and appropriate topic for your essay. Checking essay examples is first step of discovering the answer of how to initiate a college essay. The Essay Titles Samples Trap An essay has become the most common sort of academic paper assigned at the school and college level on any sort of topic, with the most important aim to cover a specific parcel of information in the most in-depth way. If you experience a writer's block try utilizing essay introduction generator to provide you with some tips on how to proceed. Naturally, the tone of your essay has an important part in making an ideal title. Very good titles for es says supply the possible audience with the role of reading the paper in the very first place. A title may be the determining factor whenever someone is picking a book to purchase. Very often, it is a critical factor when somebody is selecting a book to purchase. Such working title might just remind the author of the principal focus and idea of writing. Ultimately, the combining title connects the prior ones and makes a more powerful effect on readers. Titling an essay is not ever an easy thing. If appropriate and relevant to the discipline, even part of song lyric can serve exactly the same purpose. In creative assignments, it's possible to apply a very long song lyric. Where to Find Essay Titles Samples Our essay typers have a diverse wisdom and access to a huge database and canthus deliver the precise academic content that you need. Place your purchase, list main instructions, and you'll be assigned with a skilled academic writer. It's simple to use, has many features, and is an enjoyable means of developing a title. The rich selection of our essay typer service s will allow you to attain much better grades. There are a lot of sources you may utilize. It's simpler to develop the appropriate title knowing the whole essay's structure and the arguments discussed. Thus, there's no preview about the aim of your study. Among the factors is the way to title an essay. You want to make a productive essay title page for it. The three expert help will help to how to select a title for an essay. You may specify a title for your essay on your own, or you'll be able to use essay title generator. Therefore, if you don't find out how to title an essay effectively, here are a few suggestions and suggestions for you to address. Here's What I Know About Essay Titles Samples If you think about creating titles easy and you don't require any narrative essay prompts college or higher school students want to follow, it is genuinely great. To make things worse, crafting a superb title is not a simple feat. If you're one of the numerous students that are requested to write about Romeo and Juliet and it's still true that you find it difficult to look for good and inspiring title for your work, then, you don't need to worry. Each student desires the maximum grade.

Essay about The Psychology behind Keeping or Losing...

In 1997, the Adoption and Safe Families Act was passed to specifically address the health and welfare of foster children. It established strict time lines for children to be returned to their parents, or terminate parental rights so children could be adopted. In cases of sexual and chronic physical abuse, the ASFA authorized states to dispense with efforts to reunify the family and move directly to termination of parental rights (Myers, 2006, p. 102). In summary, the many advances in the child welfare protections suggest an evolving recognition of the special protections that children need and require. â€Å"From the colonial period well into the 19th century, childhood was not considered a special phase of human development. For the most†¦show more content†¦It is therefore not surprising that in many situations the concept of â€Å"sparing the rod and spoiling the child† has been passed down generationally, sometimes to the point where abuse is an end result (Cro sson-Tower, 2010). The child protection movement had a peculiar start as it evolved out the animal protection movement organized by Henry Bergh, who had gained attention from the community leaders of New York while tending to mistreated animals (Watkin, 1990). In 1874, the beatings and repeated maltreatment of a young girl by the name of Mary Ellen Wilson was brought to the attention of a church worker named Etta Wheeler (Watkin, 1990). Ms. Wheeler pleaded with both Henry Bergh and attorney Elbridge Gerry to prosecute the stepmother (Mrs. Mary Connelly) for abusing the child (Watkin, 1990). Mrs. Connelly was eventually sentenced to a year of prison labor, and Mary Ellen was removed from the home and placed in the care of Sally Angell, the mother of Etta Wheeler. This effort to rescue one child was the impetus for the formation of the Society for the Prevention of Cruelty to Children (SPCC), and in 1875. The New York Office of the SPCC was established by Elbridge Gerry and quick ly spread to Philadelphia and Chicago (Crosson-Tower, 2010). Throughout the early 20th century, advocates for the protection of children established Children’s Bureau and the Child Welfare League of America (CWLA), but its activity was slowed as a result of World War IShow MoreRelated Censorship in the Classroom Essay2774 Words   |  12 Pagesgives us, as citizens, the right to freedom of speech, expression, etc. outside of school, any parent or community member who feels we are subjecting children to unfit materials is a threat to the literature, the classs stability, and even the teachers job within the school.    Not all parents or community members are censors, by any means. Censors have characteristics that teachers need to be aware of. All of us censor ourselves at one point or another, keeping ourselves from swearingRead MoreYoung People Essay14812 Words   |  60 Pagesthe worker it is a right to training, opportunities for personal development, and support through supervision, target setting that is realistic and attainable, good employment practice and a safe working environment. The right to complain and the knowledge how to do so. For the young person the right to have own physical needs met, the right to be informed of their rights, the right to education, the right to choose, the right to participate, the right to be safe, the right to have rules thatRead MoreStephen P. Robbins Timothy A. Judge (2011) Organizational Behaviour 15th Edition New Jersey: Prentice Hall393164 Words   |  1573 PagesCredits and acknowledgments borrowed from other sources and reproduced, with permission, in this textbook appear on the appropriate page within text. Copyright  © 2013, 2011, 2009, 2007, 2005 by Pearson Education, Inc., publishing as Prentice Hall. All rights reserved. Manufactured in the United States of America. This publication is protected by Copyright, and permission should be obtained from the publisher prior to any prohibited reproduction, storage in a retrieval system, or transmission in any formRead MoreThis is an chapter by chapter summary of the book Becoming Attached, did it for extra credit11157 Words   |  45 Pagesknows is of the sucking of the breast or bottle. Another important concept in this chapter is that Bowlby thought that babies were capable of feeling a lost of a specific loved one. Weather it was through the anxiety the mother passed through after losing her husband or through not having the mother nearby. Bowlby said that there were three reactions that a baby had to separation: protest, despair, and detachment. 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It was distributed under the provisions of the Library Distribution Act and Government Code Section 11096.  ©2010 by the California Department of Education All rights reserved ISBN 978-8011-1708-4 Ordering Information Copies of this publication are available for sale from the California Department of Education. For prices and ordering information, please visit the Department Web site at http://www.cde.caRead MoreDeveloping Management Skills404131 Words   |  1617 Pagesand reproduced, with permission, in this textbook appear on appropriate page within text. Copyright  © 2011, 2007, 2005, 2002, 1998 Pearson Education, Inc., publishing as Prentice Hall, One Lake Street, Upper Saddle River, New Jersey 07458. All rights reserved. Manufactured in the United States of America. This publication is protected by Copyright, and permission should be obtained from the publisher prior to any prohibited reproduction, storage in a retrieval system, or transmission in any form

Cost Classification Hersheys Chocolates - 2168 Words

Table of ContentsIntroduction1Part 111.1 Product Chosen - Hersheys Kisses.11.2 Cost Classification21.3 Explanations3Part 252.1 Production process.52.2 Type of product costing - Process costing62.3 Differences between management accounting (MA) and financial accounting (FA) - cost of inventory7Part 38References10Appendices12IntroductionThe Hershey Company (Hershey) was the chosen listed manufacturing company which to be discussed in this assignment. They are the largest North American manufacturer of quality chocolate and sugar confectionery products (The Hershey Company, 2009a). Part 11.1 Product Chosen - Hersheys Kisses. Hersheys Kisses are a type of chocolate manufactured by The Hershey Company. The bite-sized pieces of chocolate†¦show more content†¦That is, the machines total depreciation expense is the same each year regardless of volume produced on the machine. Occasionally, there are also curvilinear costs, for example cost of electricity, when market demand for Hersheys Kisses rises, electricity costs will increase at an increasing rate and vice versa. Besides that, most of the variable costs within Hersheys production department are thought to be controllable in short period of time; conversely, many fixed costs areuncontrollable in the short term (U.S Department of Education, 2007). For instance, Hersheys production managers could make decision on resources allocations which may influence the efficiency such as reduce direct labours overtime or control of the quantity of raw materials used for production; however, Hersheys production manager may not be able to influence the factory rental charged by the landlord. The value chain is a set of linked processes or activities which includes the upstream costs, downstream costs and the production costs or manufacturing cost (Blocher, Stout, Cokins, Kung, 2005). Some upstream costs found in production of Hersheys Kisses would be Research and Development costs that conducted by Hershey to produce higher quality Hersheys Kisses; wages of the designer on designing new packaging of Hersheys Kisses would be the designShow MoreRelatedMarketing Is Discovering And Satisfying Consumer Needs1116 Words   |  5 Pages Question #1 (6 Marks) The first objective in marketing is discovering and satisfying consumer needs. Explain the consumer insight that led to the re-launch of Hershey’s new chocolate bar. The consumer’s of the Take 5 chocolate bar were in their late teens and young adulthood who still enjoyed their brakes with tasteful treats. The target users were asked to give a comparison between the other treats that were available along with the Take 5. 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Hershey’s bought Cadbury’s US operations in 1988 and license the recipes from Cadbury to create US versions of Cadbury’s original candies. So Hershey essentially puts an embargo on any Cadbury or foreign chocolate they don’t want sold in the US, and it is perfectly legal becaus e of US trademarkRead MoreChocolate Industry8116 Words   |  33 PagesContents Titles 1. Introduction 2. Objective 3. Research Methodology 4. Chocolate Industry 5. Chocolate in a Bloom 6. Chocolate Industry in India 7. Major Players 8. Amul 9. Nestle 10. Cadbury 11. SWOT analysis of Cadbury 12. Market Segmentation 13. Psychographics and Demographics 14. Product Positioning 15. Product Market Boundary 16. Price Sensitivity 17. Consumer Buying Behaviour 14. Industry Structure and Dynamics 15. The Rural Conundrum 16. Key Success Factors 17. 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Organizational buying is __________. a. the process by which organizations recognize their needs for goods and services b. a way a company can produce a greater variety of high-quality products at lower cost, in less time, with less labor c. the decision-making process by which organizations establish and satisfy their needs for goods and services (difficult) p. 102 d. the practice of establishing of strategic partnerships between manufacturers and theirRead MoreAccounting 1-4 Chapter100452 Words   |  402 Pagesbusiness decisions. Marketing: A marketing specialist at a company like Procter Gamble develops strategies to help the sales force be successful. But making a sale is meaningless unless it is a profitable sale. Marketing people must be sensitive to costs and benefits, which accounting helps them quantify and understand. Finance: Do you want to be a banker for Citicorp, an investment analyst for Goldman Sachs, a stock broker for Merrill Lynch? These fields rely heavily on accounting. In all of them

Steinberg V the Chicago Medical School Free Essays

string(205) " fee to the school amounted to an offer; that the school’s voluntary reception of his fee constituted an acceptance and because of these events a contract was created between the school and himself\." Steinberg v The Chicago Medical School Appellate Court of Illinois, First District, Third Division. Mejda, P. J. We will write a custom essay sample on Steinberg V the Chicago Medical School or any similar topic only for you Order Now , and McGloon, J DEMPSEY, Justice: In December 1973 the plaintiff, Robert Steinberg, applied for admission to the defendant, the Chicago Medical School, as a first-year student for the academic year 1974–75 and paid an application fee of $15. The Chicago Medical School is a private, not-for-profit educational institution, incorporated in the State of Illinois. His application for admission was rejected and Steinberg filed a class action against the school, claiming that it had failed to evaluate his application and those of other applicants according to the academic entrance criteria printed in the school’s bulletin. Specifically, his complaint alleged that the school’s decision to accept or reject a particular applicant for the first-year class was primarily based on such nonacademic considerations as the *806 prospective student’s familial relationship to members of the school’s faculty and to members of its board of trustees, and the ability of the applicant or his family to pledge or make payment of large sums of money to the school. The complaint further alleged that by using such unpublished criteria to evaluate applicants the school had breached the contract, which Steinberg contended was created when the school accepted his application fee. In his prayer for relief Steinberg sought an injunction against the school prohibiting the continuation of such admission practices, and an accounting of all application fees, donations, contributions and other sums of money collected by the school from its applicants during a ten-year period prior to the filing of his suit. He did not ask the court to direct the school to admit him, to review his application or to return his fee. The defendant filed a motion to dismiss, arguing that the complaint failed to state a cause of action because no contract came into existence during its transaction with Steinberg inasmuch as the school’s informational publication did not constitute a valid offer. The trial court sustained the motion to dismiss and Steinberg appeals from this order. The 1974–75 bulletin of the school, which was distributed to prospective students, epresented that the following criteria would be used by the school in determining whether applicants would be accepted as first-year medical students: ‘Students are selected on the basis of scholarship, character, and motivation without regard to race, creed, or sex. The student’s potential for the study and practice of medicine will be evaluated on the basis of academic achievement, Medical College Admission Test results, p ersonal appraisals by a pre-professional advisory committee or individual instructors, and the personal interview, if requested by the Committee on Admissions. In his four-count complaint Steinberg alleged, in addition to his claim that the school breached its contract (Count I), that the school’s practice of using selection standards which were not disclosed in the school’s informational brochure, constituted a violation of the Consumer Fraud and Deceptive Business Practices Act (Ill. Rev. Stat. , **589 1973, ch. 121 1/2, par. 261, et seq. ) and of the Uniform Deceptive Trade Practices Act (Ill. Rev. Stat. , 1973, ch. 121 1/2, par. 311, et seq. ) (Count II); fraud (Count III), and unjust enrichment (Count IV). Since we are in accord with the trial court’s decision that the complaint did not state a cause of action under Counts II, III and IV, we shall limit our discussion to Count I. A contract is an agreement between competent parties, based upon a consideration sufficient in law, to do or not do a particular thing. It is a promise or a set of promises for the breach of which the law gives a *807 remedy, or the performance of which the law in some way recognizes as a duty. Rynearson v. Odin-Svenson Development Corp. (1969), 108 Ill. App. 2d 125, 246 N. E. 2d 823. A contract’s essential requirements are: competent parties, valid subject matter, legal consideration, mutuality of obligation and mutuality of agreement. Generally, parties may contract in any situation where there is no legal prohibition, since the law acts by restraint and not by conferring rights. Berry v. De Bruyn (1898), 77 Ill. App. 359. However, it is basic contract law that in order for a contract to be binding the terms of the contract must be reasonably certain and definite. Kraftco Corp v. Koblus (1971), 1 Ill. App. 3d 635, 274 N. E. 2d 153. A contract, in order to be legally binding, must be based on consideration. Wickstrom v. Vern E. Alden Co. (1968), 99 Ill. App. 2d 254, 240 N. E. 2d 401. Consideration has been defined to consist of some right, interest, profit or benefit accruing to one party or some forbearance, disadvantage, detriment, loss or responsibility given, suffered or undertaken by the other. Riddle v. La Salle National Bank (1962), 34 Ill. App. 2d 116, 180 N. E. 2d 719. Money its a valuable consideration and its transfer or payment or promises to pay it or the benefit from the right to its use, will support a contract. In forming a contract, it is required that both parties assent to the same thing in the same sense (La Salle National Bank v. International Limited (1970), 129 Ill. App. 2d 381, 263 N. E. 2d 506) and that their minds meet on the essential terms and conditions. Richton v. Farina (1973), 14 Ill. App. 3d 697, 303 N. E. 2d 218. Furthermore, the mutual consent essential to the formation of a contract, must be gathered from the language employed by the parties or manifested by their words or acts. The intention of the parties gives character to the transaction and if either party contracts in good faith he is entitled to the benefit of his contract no matter what may have been the secret purpose or intention of the other party. Kelly v. Williams (1911), 162 Ill. App. 571. Steinberg contends that the Chicago Medical School’s informational brochure constituted an invitation to make an offer; that his subsequent application and the submission of his $15 fee to the school amounted to an offer; that the school’s voluntary reception of his fee constituted an acceptance and because of these events a contract was created between the school and himself. You read "Steinberg V the Chicago Medical School" in category "Papers" He contends that the school was duty bound under the terms of the contract to evaluate his application according to its stated standards and that the deviation from these standards not only breached the contract, but amounted to an arbitrary selection which constituted a violation of due process and equal protection. He concludes that such a breach did in fact take place each and every time during the past ten years that the school evaluated applicants according to their *808 relationship to the school’s faculty members or members of its board of trustees, or in accordance with their ability to make or pledge large sums of money to the school. Finally, he asserts that he is a member and a proper representative of the class that has been damaged by the school’s practice. The school counters that no contract came into being because informational brochures, such as its bulletin, do not constitute **590 offers, but are onstrued by the courts to be general proposals to consider, examine and negotiate. The school points out that this doctrine has been specifically applied in Illinois to university informational publications. People ex rel. Tinkoff v. Northwestern University (1947), 333 Ill. App. 224, 77 N. E. 2d 345. In Tinkoff, a rejected applicant sued to force Northwestern to admit him , claiming that the university had violated the contract that arose when he demonstrated that he had met the school’s academic entrance requirements and had submitted his application and fee. His primary contention was that the school’s brochure was an offer and that his completion of the acts, required by the bulletin for application, constituted his acceptance. In rejecting this argument, the court stated: ‘Plaintiffs complain Tinkoff, Jr. was denied the right to contract as guaranteed by the Illinois and United States constitutions. We need only say that he had no right to contract with the University. His right to contract for and pursue an education is limited by the right which the University has under its charter. We see no merit to plaintiff’s contention that the rules and regulations were an offer of contract and his compliance therewith and acceptance giving rise to a binding contract. The wording of the bulletin required further action by the University in admitting Tinkoff, Jr. before a contract between them would arise. ‘ The court based its holding on the fact that Northwestern, as a private educational institution, had reserved in its State charter the right to reject any application for any reason it deemed adequate. Although the facts of the Tinkoff case are similar to the present situation, we believe that the defendant’s reliance upon it is misplaced. First, Steinberg is not claiming that his submission of the application and the $15 constituted an acceptance by him; he is merely maintaining that it was an offer, which required the subsequent acceptance of the school to create a contract. Also, it is obvious that his assertion that the bulletin of the school only amounted to an invitation to make an offer, is consistent with the prevailing law and the school’s own position. More importantly, Steinberg is not requesting that the school be ordered to admit him as a student, pursuant to the contract, but only that the school be prohibited from misleading prospective students by stating *809 in its informational literature, evaluation standards that are not subsequently used in the selection of students. Furthermore, the school does not allege, nor did it demonstrate by way of its bulletin or its charter that it had reserved the right to reject any applicant for any reason. It only stated certain narrow standards by which each and every applicant was to be evaluated. In relation to the preceding argument, the school also maintains that the $15 application fee did not amount to a legal consideration, but only constituted a pre-contracting expense. Consequently, the school argues that as a matter of law the $15 is not recoverable as damage even if a contract was eventually entered into and breached. Chicago Coliseum Club v. Dempsey (1932), 265 Ill. App. 542. In the Dempsey case, boxing promoters incurred expenses and entered into several contracts that were necessary for the staging of a heavyweight championship fight. However, most of the contracts were entered into prior to signing Dempsey (the then heavywright champion) for the event. For example, approximately a week prior to Dempsey’s signing, the plaintiff entered into a contract with a fighter named Wills, who was to be the champion’s opponent. Dempsey signed a contract but later breached it, and the fight promoters sued him for expenses incurred by them under the Wills contract and under other contracts **591 which had been entered into by them in anticipation of the champion signing a contract and fulfilling his obligation thereunder. The court stated: ‘The general rule is that in an action for a breach of contract a party can recover only on damages which naturally flow from and are the result of the act complained of. . . . The Wills contract was entered into prior to the contract with the defendant and was not made contingent upon the plaintiff’s obtaining a similar agreement with the defendant Dempsey. Under the circumstances the plaintiff speculated as to the result of his efforts to procure the Dempsey contract. . . Any obligations assumed by the plaintiff prior to that time (of contracting with Mr. Dempsey) are not chargeable to the defendant. ‘ The defendant’s reliance on the Dempsey case is also misplaced. Although it is a leading case for the proposition that expenses incurred during preliminary negotiations to procure a contract are not recoverable as damages, it has no relevance to the allegations of Steinberg’s complaint. The defendant misconceives and misstates his po sition when it asserts that the Tinkoff and Dempsey cases ‘are completely ispositive of plaintiff’s argument that the informational brochure constituted an ‘offer’ to evaluate applicants solely on the basis of criteria set forth therein, and the submission of an application with the $15. 00 fee the ‘consideration’ *810 binding that offer and effecting a consummated contract. ‘ He does not claim that the brochure was an offer and his submission of a fee an acceptance of that offer. To repeat, what he does claim is that the brochure was an invitation to make an offer; that his response was an offer, and that the school’s retention of his fee was an acceptance of that offer. We agree with Steinberg’s position. We believe that he and the school entered into an enforceable contract; that the school’s obligation under the contract was stated in the school’s bulletin in a definitive the school’s stated criteria. application fee–a valuable consideration–the school bound itself to fulfill its promises. Steinberg accepted the school’s promises in good faith and he was entitled to have his application judged according to the school’s stated creiteria. The school argues that he should not be allowed to recover because his complaint did not state a causal connection between the rejection of his application and the school’s alleged use of unpublished evaluation criteria. It points out that there is an equal probability that his application was rejected for failing to meet the stated standards, and since the cause of his damages is left to conjecture they may be attributed as easily to a condition for which there is no liability as to one for which there is. This argument focuses on the wrong point. Once again, Steinberg did not allege that he was damaged when the school rejected his application. He alleged that he was damaged when the school used evaluation criteria other than those published in the school’s bulletin. This ultimate, well-pleaded allegation was admitted by the school’s motion to dismiss. Logan v. Presbyterian-St. Luke’s Hospital (1968), 92 Ill. App. 2d 68, 235 N. E. 2d 851. The primary purpose of pleadings is to inform the opposite party and the court of the nature of the action and the facts on which it is based. The Civil Practice Act of Illinois provides that pleadings shall be liberally construed to the end that controversies may be settled on their merits. Jorgensen v. Baker (1959), 21 Ill. App. 2d 196, 157 N. E. 2d 773; Ill. Rev. Stat. , 1973, ch. 110, par. 33(3). Therefore, a cause of action should not be dismissed unless it clearly appears that no set of facts can be proven under the pleadings which will entitle the plaintiff to recover. **592 Herman v. Prudence Mutual Casualty Co. (1968), 92 Ill. App. 2d 222, 235 N. E. 2d 346. Additionally, a complaint will not be dismissed for failure to state a cause of action if the facts essential to its claim appear by reasonable implication. Johnson v. Illini Mutual Insurance Co. (1958), 18 Ill. App. 2d 211, 151 N. E. 2d 634. A complaint is not required to make out a case which will entitle the plaintiff to all of the sought-after relief, but it need only raise a fair question as to the existence of the right. People ex rel. Clark v. McCurdie (1966), 75 Ill. App. 2d 217, 220 N. E. 2d 318. Count I of Steinberg’s complaint stated a valid cause of action, and the portion of the trial court’s order dismissing that count will be reversed and remanded. Alternatively, the school asserts that if Steinberg is entitled to recover, the recovery should be limited to $15 because he is not a proper representative of the class of applicants that was supposed to be damaged by the school’s use of unpublished entrance standards. Fundamentally, it argues that it had no contract with Steinberg and since he does not have a cause of action, he cannot represent a class of people who may have similar claims. We have found, however, that he does have a cause of action. The primary test for the validity of a class action is whether the members of the class have a community of interest in the subject matter and the remedy. Smyth v. Kaspar American State Bank (1956), 9 Ill. 2d 27, 136 N. E. 2d 796. Even if the wrongs were suffered in unrelated transactions, a class action may stand as long as there are common factual and legal issues. Gaffney v. Shell Oil Co. (1974), 19 Ill. App. 3d 987, 312 N. E. 2d 753. The legal issue in this case would be the same as to each member of the class, and the factual issue–the amount payed by each member, an application fee of $15– identical. Steinberg alleged that in applying for admission to the school, each member of the class assumed that the school would use the selection factors set out in its 1974–75 bulletin, and that admission fees were paid and contracts created, but that each contract we breached in the same manner as his. This allegation established a community of interest between him and the other members of the class in terms of subject matter and remedy, and since he has a valid cause of action against the school, the class has also. He is a proper representative of the class and his suit is a proper vehicle to resolve the common factual and legal issues involved even though the members of the class suffered damage in separate transactions. However, the class action cannot be as extensive as Steinberg’s complaint requested. Recovery cannot be had by everyone who applied to the medical school during the ten years prior to the filing of his complaint. His action was predicated on standards described in the school’s 1974–75 brochure; therefore, the class to be represented is restricted to those applicants who sought admission in reliance on the standards in that brochure. We agree with the school’s contention that a State through its courts does not have the authority to interfere with the power of the trustees of a private medical school to make rules concerning the admission of students. The requirement in the case of public schools, applicable because they belong to the public, that admission regulations *812 must be reasonable is not pertinent in the case of a private school or university. 33 I. L. P. Schools, s 312. We also agree that using unpublished entrance requirements would not violate an applicant’s right to due process and equal protection of law. The provisions of the due process clause of the Federal constitution are inhibitions upon the power of government and not upon the freedom of action of private individuals. 16 Am. Jur. 2d, **593 Constitutional Law, sec. 557. The equal protection clause of the 14th Amendment does not prohibit the individual invasion of individual rights. Gilmore v. City of Montgomery (1974), 417 U. S. 556, 94 S. Ct. 2416, 41 L. Ed. 2d 304. The order dismissing Counts II, III and IV is affirmed. The order dismissing Count I is reversed. The cause is remanded for further proceedings not inconsistent with the views expressed in this opinion. Affirmed in part; reversed in part and remanded with directions. MEJDA, P. J. , and McGLOON, J. , concur. How to cite Steinberg V the Chicago Medical School, Papers

Molecular Biology Genes & Diseases

Question: Discuss about theMolecular Biology for Genes Diseases. Answer: Introduction The insulin-like growth factor family consists of three peptide hormones that include insulin, IGF-1 and IGH-2. They have 50% of their amino acid sequences in common (Le Roith 1997). They play a critical role in growth, differentiation and metabolism in almost every cell of the human body. Due to its diverse and far reaching roles it has been associated with several diseases and disorders and is a potential target for therapeutic intervention (Forbes 2016). IGF signaling is associated with decreased cell death and increased cell proliferation. Activation of IGF-1R leads to the activation of two pathways, PI3K/AKT and Ras/MAPK. PI3K/AKT pathway ultimately leads to decreased apoptosis, increased glucose metabolism, increased protein synthesis. On the other hand Ras/MAPK pathway leads to increased cellular proliferation by activating different transcription factors, such as ELK1. Cancer cell proliferation, migration and invasion have been related to the activation of IGF-1R in many studies previously (Sachdev and Yee 2007). Cancers in lung, breast, colon, prostate are showed to be associated with increased level of plasma IGF (Pollak, Schernhammer and Hankinson 2004). Other members of IGF pathway are also proved to be involved with malignancies. This provides a way to treat cancers via modulating IGF pathway and various ligands involved with it. Drug resistance by tumors is one of the critical conditions in new age cancer treatment. As IGF pathway is involved in cell proliferation it shows a new era of treating these kinds of situations. Many studies have shown that modulating IGF pathway has promising effect in these cases (Denduluri et al. 2015). Ovarian cancer is the fifth most frequent cause of cancer death in women. In nearly half of ovarian and breast cancer patients, RAB25 mRNAs were found to be selectivey overexpressed at stage 3 and 4 serous epitheli al ovarian cancers in comparison to other genes located in the amplified region. Decreased expression of two proteins BAK and BAX were found to be associated with an inhibition of apoptosis in such cells. Simultaneously activation of PI3K/AKT pathway provided potential mechanisms to employ the effects of RAB25 on tumor aggressiveness (Lee et al. 2015). Involvement of PI3k/AKT pathway in the RAB25 related tumor aggressiveness leads to the way to treatment by modulating this pathway. Recently various evidences show that IGF-1 promotes atherosclerotic plaque stability and consequently reduces atherosclerosis in animal models. IGF-1 induces reduction of oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction, that helps prevent the disease. Aging has been widely linked with increased vascular oxidative stress and certain vascular diseases (Barzilai et al. 2012). It has been postulated IGF-1 may play a crucial role on vascular aging processes. There are various evidences that IGF-1 exerts pleiotropic effects on the vasculature resulting in reduced vascular oxidative stress, apoptosis, and inflammatory signaling pathway (Higashi et al. 2012). By modulating IGF signaling disease related to stress or premature cell death or decreased cell death can be prevented in future. Further studies on signaling pathway of IGF show its potential role in regulation of autoimmune diseases. Though this area of treatment requires a lot more research and practical approaches, the role of IGF signaling is competent enough. Studies show that IGF-I can potentially protect animal models from developing insulin-deficient diabetes mellitus (Gao et al. 2011). On the contrary, patients with Graves disease have shown an overexpression of the IGF-1R in many cell types and antibodies against the receptor were prevalent in such patients. The frequency of IGF-IR positive B and T cells were found to be relatively high in patients with the disease. Hence, as IGF-1 and IGF-1R is found to be linked with the mentioned autoimmune disease modulation of the pathway might be a potential therapeutic target for managing the diseases and alleviating the health consequences (Smith 2010). The modulation of IGF pathway opens new ways to treat various diseases like different types of cancer, cellular stress-related diseases and immunological diseases also. It depends totally on massive research and practically showing the results on animal models to prove the modulation of IGF pathway actually showing some positive results. Comparative Genomic Hybridization: Comparative Genomic hybridization is a comparative study of two genomes by in situ hybridization technique that allows detection of differences in DNA sequences between the two genomes. Two genomes, one study and one reference genomes are differentially labeled after being denatured into single stranded DNA (Pinkel and Albertson 2005). These two genomes are then hybridized to normal metaphase spreads or to microarray. Ratio of the fluorescence intensity are then measured And plotted on a graphical manner. The graph can reveal locations of copy number changes in along the target chromosome or DNA sequences. It has been extensively used to identify genetic differences between normal cells and certain diseased cells mostly in cancer cell biology. It efficiently detects any gain or loss of genetic material in human genetic disorders by comparing the same with a reference genome, often a relevant normal cell genome. Primarily the effect of stable expression of Rab25, a hallmark of cancer has been assayed in all the parts of Figure 2. Other hallmarks that were also assayed were Bak and Bax nuclear proteins. Bak and Bax are two nuclear-encoded proteins that are capable of moving through mitochondrial membrane and induce cell death by apoptosis. Phosphorylation of AKT was also assayed during stable expression of Rab25 and in presence of RNAi. AKT or protein kinase B (PKB) is a protein kinase that plays key roles several cellular functions including apoptosis. Viral-mediated transduction is the most potent technique to produce stable cell lines with a overexpressing protein. Vectors are utilized for this purpose. Vectors are autonomously replicating DNA molecules that can be used to transfer DNA fragments to cells of interest. For transfecting mammalian cells, vectors derived from mammalian viruses are used that include Simian viruses (SV40), polyomavirus, herpesvirus and papovirus (Khan 2013). The Rab25 gene can be inserted into any one of the vector mentioned and the same gene can be transferred to an appropriate mammalian cell line by viral transfection. Mammalian cell lines that are extensively used for this purpose are HeLa, HEK293T, U2OS so on and so forth. Compared to transient transfection, stable transfected cell lines are produced to analyze impact of altered gene expression over a long time period. Generally, antibiotic resistance or fluorescent reporter cell markers are incorporated into plasmid or vector DNA to create selectio n criteria. Clonal Selection can be done by appropriate selection controls. The selected colony is used to produce monoclonal cell line development and consequently producing a stable cell line generation. The expression and stability is checked on a regular basis. The construct expression is then validated by qRT-PCR and/or Western blot techniques. Assay (e) was performed to evaluate the levels of Bak and Bax proteins in the four different ovarian cancer cell lines namely A2780 and hey and immortalized ovarian cancer cell lines T29 and T80 where there is overexpression of the protein Rab25. Bak protein levels are found to be lower in Rab25 expressing A2780, HEY and T29 cells as compared to pcDNA cells. In T80 cell lines Bak was overexpressed showing that Bak levels are regulated by other factors in certain cells. Bax levels were low in A2780 and Hey cells but not in T29 and T80 cells. In assay (f) Bak and Bax levels were measured in A2780 cells were Rab25 expression is downregulated by RNAi. The downregulation of Rab25 nullified Rab25 mediated inhibition of Bak and Bax and hence the two protein levels were found to be high in the cell lines. Bak and Bax are two nuclear proteins that can travel to mitochondrial outer membrane upon activation of relevant signaling pathway and is essential for mitochondrial permiabilisation during apoptosis (Dewson and Kluck 2009). These two proteins play a significant role in intrinsic apoptotic pathway in mammalian cells and as a result they have being extensively studied for therapeutic purposes to block apoptosis. Motility of cells where Rab25 is overexpressed or knocked down can be assayed by standard apoptotic assay methods. Cleavage of the genomic DNA into discrete fragments and consequently membrane disintegration are key features that occur during apoptosis and cell-mediated cytotoxicity. DNA cleavage being hallmark of apoptosis is often measured to assay apoptotic cell death. The DNA fragments can be assayed by ELISA quantification of histone-complexed DNA fragments. Furthermore, caspases are a class of protein that are expressed and involved in the early stages of apoptosis. Activation of the caspase proteins can be assay to determine the stage of apoptosis in a cell (Suzuki, Nakabayashi and Takahashi 2001). This can be done by in vitro enzyme assay or by detection of cleavage of an in vivo caspase substrate. Furthermore to assess the motility transwell migration assay can be performed to assess cell movement and migration. In Transwell migration assay there are two chambers; the cell s uspension placed on the upper chamber and chemoattractants are placed in the lower chamber. Cells that are motile will migrate through the membrane and get attached to the lower side of the upper chamber; non-migratory cells will remain on the upper chamber. The migratory cells can then be labeled and quantified to assess the motility of the cell lines with overexpressed and knocked out Rab25 protein. References Barzilai, N., Huffman, D.M., Muzumdar, R.H. and Bartke, A., 2012. The critical role of metabolic pathways in aging.Diabetes,61(6), pp.1315-1322. Denduluri, S.K., Idowu, O., Wang, Z., Liao, Z., Yan, Z., Mohammed, M.K., Ye, J., Wei, Q., Wang, J., Zhao, L. and Luu, H.H., 2015. Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance.Genes Diseases,2(1), pp.13-25. Dewson, G. and Kluck, R.M., 2009. Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.Journal of cell science,122(16), pp.2801-2808. Forbes, B.E., 2016. Two years in IGF research.Growth Hormone IGF Research. Gao, J., Chesebrough, J.W., Cartlidge, S.A., Ricketts, S.A., Incognito, L., Veldman-Jones, M., Blakey, D.C., Tabrizi, M., Jallal, B., Trail, P.A. and Coats, S., 2011. Dual IGF-I/IIneutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth.Cancer research,71(3), pp.1029-1040. Higashi, Y., Sukhanov, S., Anwar, A., Shai, S.Y. and Delafontaine, P., 2012. Aging, atherosclerosis, and IGF-1.The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, p.gls102. Khan, K.H., 2013. Gene expression in mammalian cells and its applications.Adv Pharm Bull,3(2), pp.257-63. Lee, J.S., Kang, J.H., Boo, H.J., Hwang, S.J., Hong, S., Lee, S.C., Park, Y.J., Chung, T.M., Youn, H., Lee, S.M. and Kim, B.J., 2015. STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody.Nature communications,6. Pinkel, D. and Albertson, D.G., 2005. Comparative genomic hybridization.Annu. Rev. Genomics Hum. Genet.,6, pp.331-354. Pollak, M.N., Schernhammer, E.S. and Hankinson, S.E., 2004. Insulin-like growth factors and neoplasia.Nature Reviews Cancer,4(7), pp.505-518. Sachdev, D. and Yee, D., 2007. Disrupting insulin-like growth factor signaling as a potential cancer therapy.Molecular cancer therapeutics,6(1), pp.1-12. Smith, T.J., 2010. Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?.Pharmacological reviews,62(2), pp.199-236. Suzuki, Y., Nakabayashi, Y. and Takahashi, R., 2001. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.Proceedings of the National Academy of Sciences,98(15), pp.8662-8667.